Your doctor may adjust your dose as needed
Literature regarding the safety and efficacy of dosing allopurinol in CKD has shown inconsistent results and is based primarily on retrospective, case cohort or observational data
Allopurinol use, initiated at a dose of at least 300 mg/d, was associated with a 13% reduction in the risk of developing CKD stage 3 or higher
By this, the prevalence of elevated serum UA in patients with chronic kidney disease (CKD) is higher
) Precautions – We discourage increasing colchicine beyond standard doses
Renal failure associated with allopurinol has been observed in patients with hyperuricemia secondary to neoplastic diseases
Limiting max dose of allopurinol to a renally adjusted dosage often undertreats gout
Extra caution should be exercised if renal function is poor (see section 4
Some trials have demonstrated an increased risk of allopurinol-induced adverse reactions in patients with CKD, whereas others have not confirmed renal
Allopurinol oral tablet (Zyloprim) is an oral drug used to decrease uric acid levels
Description and guidelines for prevention in patients with renal insufficiency
Clin Phar-macokinet
People with CKD have an increased prevalence of cardiovascular disease (CVD)
Neogi said it’s because of a decades-old concern, “unsupported by any evidence, that higher doses may be detrimental in people with renal insufficiency